isaiah 25:2 For thou hast made of a city an heap; of a defenced city a ruin: a palace of strangers to be no city; it shall never be built. - Free Bible Online

      2. a city . . . heap--Babylon, type of the seat of Antichrist, to be destroyed in the last days (compare Jer 51:37, with Re 18:1-24, followed, as here, by the song of the saints' thanksgiving in Re 19:1-21). "Heaps" is a graphic picture of Babylon and Nineveh as they now are.
      palace--Babylon regarded, on account of its splendor, as a vast palace. But MAURER translates, "a citadel."
      of strangers--foreigners, whose capital pre-eminently Babylon was, the metropolis of the pagan world. "Aliens from the commonwealth of Israel, strangers from the covenants of promise" (Isa 29:5; Eph 2:12; see in contrast, Joe 3:17).
      never be built-- (Isa 13:19, 20, &c.).

JFB.